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Article

Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg.

DNA repair - 10 Dec 2011

van de Vrugt Henri J, Koomen Mireille, Bakker Sietske, Berns Mariska A D, Cheng Ngan Ching, van der Valk Martin A, de Vries Yne, Rooimans Martin A, Oostra Anneke B, Hoatlin Maureen E, Te Riele Hein, Joenje Hans, Arwert Fré

Abstract excerpt

Fanconi anemia (FA) is a heritable disease characterized by bone marrow failure, congenital abnormalities, and cancer predisposition. The 15 identified FA genes operate in a molecular pathway to preserve genomic integrity. Within this pathway the FA core complex operates as an ubiquitin ligase that activates the complex of FANCD2 and FANCI to coordinate DNA repair. The FA core complex is formed by at least 12...

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Source

Identifiers

PMID: 22036606
DOI: 10.1016/j.dnarep.2011.09.015

Genes

FANCA
FANCD2
FANCG
FANCI
FANCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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