Article
[Mitochondrial DNA mutations in the pathogenesis in the head and neck squamous cell carcinoma].
Otolaryngologia polska = The Polish otolaryngology - 1 Jan 2008
Pietka Grzegorz, Kukwa Wojciech, Bartnik Ewa, Scińska Anna, Czarnecka Anna M
Abstract excerpt
Data reported until today suggested a pivotal role of nuclear DNA mutations in the process of carcinogenesis. Recently more and more authors claim that disruption of mitochondrial DNA should not be excluded from this analysis. mtDNA have been reported in many cancers of head and neck region. Mitochondrial D-loop has been proven to be mutation hot - spot with majority of mutations in the positions 303 to 315 of...
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