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Article

Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.

Journal of molecular biology - 6 Sept 2002

Hogner A, Kastrup J S, Jin R, Liljefors T, Mayer M L, Egebjerg J, Larsen I K, Gouaux E

Abstract excerpt

Glutamate is the principal excitatory neurotransmitter within the mammalian CNS, playing an important role in many different functions in the brain such as learning and memory. In this study, a combination of molecular biology, X-ray structure determinations, as well as electrophysiology and binding experiments, has been used to increase our knowledge concerning the ionotropic glutamate receptor GluR2 at the...

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Identifiers

PMID: 12215417
DOI: 10.1016/s0022-2836(02)00650-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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