Article

Downstream allosteric modulation of NMDA receptors by 3-benzazepine derivatives

2022-10-26

Abstract excerpt

<title>Abstract</title> <p>N-methyl-D-aspartate receptors (NMDARs) composed of different splice variants display distinct pH sensitivities and are crucial for learning and memory, as well as for inflammatory or injury processes. Dysregulation of the NMDAR is associated with diseases like Alzheimer’s, Huntington’s, depression and substance addiction. The development of selective receptor modulators therefore const...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2813edf-ee71-5993-b763-77a34bdee8fa
DOI: 10.21203/rs.3.rs-2169726/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Downstream allosteric modulation of NMDA receptors by 3-benzazepine derivativesDOI 10.21203/rs.3.rs-2169726/v1Read

A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.Semantic proximity Read

Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition.Semantic proximity Read

Identification of novel allosteric modulator binding sites in NMDA receptors: A molecular modeling study.Semantic proximity Read

Targeting N‐methyl‐D‐aspartate Receptors in Neurodegenerative DiseasesSemantic proximity Read

Structural insights into competitive antagonism in NMDA receptors.Semantic proximity Read

<i>In vitro</i> effects of S-Licarbazepine as a potential precision therapy on <i>SCN8A</i> variants causing neuropsychiatric disordersSemantic proximity Read

Molecular and functional diversity of the NMDA receptor channel.Semantic proximity Read

Ion channel pharmacology.Semantic proximity Read

Molecular determinants of NMDA receptor pharmacological diversity.Semantic proximity Read

7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo.Semantic proximity Read

In vitro effects of eslicarbazepine (S-licarbazepine) as a potential precision therapy on SCN8A variants causing neuropsychiatric disorders.Semantic proximity Read

7-Methoxy-3-Substituted-2,3,4,5-Tetrahydro-1<em>H</em>-benzo[<em>d</em>]azepin-1-ols as Prospective Radioligands for PET Imaging of the GluN2B SubunitSemantic proximity Read