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Article

The initiation of colon cancer in a chronic inflammatory setting.

Carcinogenesis - 1 Sept 2005

Chen Ru, Rabinovitch Peter S, Crispin David A, Emond Mary J, Bronner Mary P, Brentnall Teresa A

Abstract excerpt

Chronic inflammation predisposes to cancer. We used an inflammation-induced human model of tumorigenesis to explore how populations of mutated cells expand and initiate the earliest stages of cancer. Ulcerative colitis (UC) is a chronic inflammatory disease of the colon associated with an increased risk of colorectal cancer mediated through a process of genomic instability. In order to characterize the process of...

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PMID: 15860506
DOI: 10.1093/carcin/bgi106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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