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Article

Modifying the mouse: design and desire.

Bio/technology (Nature Publishing Company) - 1 May 1992

Bradley A, Hasty P, Davis A, Ramirez-Solis R

Abstract excerpt

Genetic modification of endogenous genes in mice has become possible by applying gene targeting techniques to embryonic stem (ES) cells and using specific clones of cells to generate mice. Despite the experimental opportunities offered by the creation of organisms with specific genetic changes, t...

Topics

Alleles
Animals
Cell Line
Clone Cells
Mice
Mice, Transgenic
Recombination, Genetic
Stem Cells
Transfection

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1368233
DOI: 10.1038/nbt0592-534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1368233-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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