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Article

Modifying the mouse: design and desire.

Bio/technology (Nature Publishing Company) - 1 May 1992

Bradley A, Hasty P, Davis A, Ramirez-Solis R

Abstract excerpt

Genetic modification of endogenous genes in mice has become possible by applying gene targeting techniques to embryonic stem (ES) cells and using specific clones of cells to generate mice. Despite the experimental opportunities offered by the creation of organisms with specific genetic changes, there are considerable technical obstacles which can confound the routine implementation of this technology. This review...

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PMID: 1368233
DOI: 10.1038/nbt0592-534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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