Article
Technical approaches for mouse models of human disease.
Disease models & mechanisms - 1 May 2011
Justice Monica J, Siracusa Linda D, Stewart A Francis
Abstract excerpt
The mouse is the leading organism for disease research. A rich resource of genetic variation occurs naturally in inbred and special strains owing to spontaneous mutations. However, one can also obtain desired gene mutations by using the following processes: targeted mutations that eliminate function in the whole organism or in a specific tissue; forward genetic screens using chemicals or transposons; or the...
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