Article
Beyond 'knock-out' mice: new perspectives for the programmed modification of the mammalian genome.
Molecular human reproduction - 1 Oct 1998
Cohen-Tannoudji M, Babinet C
Abstract excerpt
The emergence of gene inactivation by homologous recombination methodology in embryonic stem cells has revolutionized the field of mouse genetics. Indeed, the availability of a rapidly growing number of mouse null mutants has represented an invaluable source of knowledge on mammalian development,...
Topics
- Animals
- Deoxyribonucleases, Type II Site-Specific
- Forecasting
- Gene Deletion
- Gene Expression Regulation
- Genetic Engineering
- Integrases
- Mice
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Recombination, Genetic
- Saccharomyces cerevisiae Proteins
- Viral Proteins