Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development.

PLoS genetics - 1 Jan 2012

Nakdimon Itay, Walser Michael, Fröhli Erika, Hajnal Alex

Abstract excerpt

Vulval development in Caenorhabditis elegans serves as an excellent model to examine the crosstalk between different conserved signaling pathways that are deregulated in human cancer. The concerted action of the RAS/MAPK, NOTCH, and WNT pathways determines an invariant pattern of cell fates in three vulval precursor cells. We have discovered a novel form of crosstalk between components of the Insulin and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Mitogen-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Receptor, Insulin

Share to Receptors, Notch

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22916028
DOI: 10.1371/journal.pgen.1002881
PMCID: PMC3420937

Genes

PTEN
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development.PMID 22916028Read ↗

Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.Semantic proximity Read ↗

A role for C. elegans Eph RTK signaling in PTEN regulation.Semantic proximity Read ↗

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.Semantic proximity Read ↗

Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental abnormalities in adult C. elegansSemantic proximity Read ↗

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistanceSemantic proximity Read ↗

C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites.Semantic proximity Read ↗

Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development.Semantic proximity Read ↗

sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.Semantic proximity Read ↗

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.Semantic proximity Read ↗

The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans.Semantic proximity Read ↗

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.Semantic proximity Read ↗

Role of a raf proto-oncogene during Caenorhabditis elegans vulval development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.