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Article

Tyrosine 1045 codon mutations in exon 27 of EGFR are infrequent in oral squamous cell carcinomas.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Tushar Mehta Dhaval, Ramanathan Arvind

Abstract excerpt

BACKGROUND: The activation and inactivation of receptor tyrosine kinases are tightly regulated to ensure faithful replication of cells. After having transduced extracellular growth activating signals, activated EGFR is subjected to downregulation either by clathrin mediated endocytosis or c-Cbl mediated proteasome degradation depending on the ligand concentration. c-Cbl is an ubiquitin ligase which requires a...

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Identifiers

PMID: 23991943
DOI: 10.7314/apjcp.2013.14.7.4279

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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