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Article

Lack of mutations in protein tyrosine kinase domain coding exons 19 and 21 of the EGFR gene in oral squamous cell carcinomas.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014

Mehta Dhaval Tushar, Annamalai Thangavelu, Ramanathan Arvind

Abstract excerpt

BACKGROUND: The epidermal growth factor receptor (EGFR) plays a vital role in the activation and inactivation of receptor tyrosine kinases. Mutations in exons 19 and 21 of EGFR are commonly found to be associated with non small cell lung carcinoma and triple negative breast cancer, enhancing sensitivity to EGFR targeting chemotherapeutic agents. Since amplification and prolonged activation of EGFR molecules have...

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Identifiers

PMID: 24969895
DOI: 10.7314/apjcp.2014.15.11.4623

Genes

EGFR

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