Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma.

doi:10.1016/j.ejca.2005.08.034

Article

Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma.

European journal of cancer (Oxford, England : 1990) - 1 Jan 2006

Loeffler-Ragg Judith, Witsch-Baumgartner Martina, Tzankov Alexandar, Hilbe Wolgang, Schwentner Ilona, Sprinzl Georg M, Utermann Gerd, Zwierzina Heinz

Abstract excerpt

Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are associated with increased sensitivity to tyrosine kinase inhibitors (TKIs) and are present in 10-30% of non-small cell lung carcinoma depending on ethnic origin. EGFR protein is also overexpressed in about 90% of squamous cell carcinoma of head and neck (HNSCC), and treatment with TKIs has shown clinical...

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Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma.

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