Article
Epidermal growth factor receptor mutations in patients with oral cavity cancer in a betel nut chewing-prevalent area.
Head & neck - 1 Dec 2011
Hsieh Chia-Hsun, Chang John W C, Hsieh Jia-Juan, Hsu Todd, Huang Shiu-Feng, Liao Chun-Ta, Wang Hung-Ming
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations exist in patients with oral cavity squamous cell carcinoma (OSCC), but few data about mutation patterns with clinical outcomes were reported. METHODS: Fifty-six formalin-fixed paraffin-embedded tumor samples were obtained surgically from OSCC patients. Direct sequencing of EGFR was carried out using nested polymerase chain reaction. The relationship...
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