Article
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor.
Oncogene - 20 Nov 2003
Oksvold Morten P, Thien Christine B F, Widerberg Jannicke, Chantry Andrew, Huitfeldt Henrik S, Langdon Wallace Y
Abstract excerpt
In the present study, we examined EGF-induced internalization, degradation and trafficking of the epidermal growth factor receptor (EGFR) mutated at serines 1046, 1047, 1057 and 1142 located in its cytoplasmic carboxy-terminal region. We found the serine-mutated EGFR to be inhibited in EGF-induced internalization and degradation in NIH3T3 cells. We therefore tested the hypothesis that these mutations affect...
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