Article
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.
European cells & materials - 24 Feb 2011
Goldring Mary B, Otero Miguel, Plumb Darren A, Dragomir Cecilia, Favero Marta, El Hachem Karim, Hashimoto Ko, Roach Helmtrud I, Olivotto Eleonora, Borzì Rosa Maria, Marcu Kenneth B
Abstract excerpt
Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation from superficial to deep layers and from loaded to unloaded zones. A major challenge to efforts to repair cartilage by stem cell-based and other tissue engineering strategies is the inability of the resident chondrocytes to lay down new matrix with the same structural and resilient properties that it had upon its original...
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