RBP‐Jκ–Dependent Notch Signaling Is Required for Murine Articular Cartilage and Joint Maintenance

Abstract excerpt

OBJECTIVE: Osteoarthritis (OA) is a degenerative disease resulting in severe joint cartilage destruction and disability. While the mechanisms underlying the development and progression of OA are poorly understood, gene mutations have been identified within cartilage-related signaling molecules, implicating impaired cell signaling in OA and joint disease. The Notch pathway has recently been identified as a crucial...

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