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Article

BMP7 reduces the fibrocartilage chondrocyte phenotype.

Scientific reports - 4 Oct 2021

Ripmeester Ellen G J, Caron Marjolein M J, van den Akker Guus G H, Steijns Jessica, Surtel Don A M, Cremers Andy, Peeters Laura C W, van Rhijn Lodewijk W, Welting Tim J M

Abstract excerpt

The fibrocartilage chondrocyte phenotype has been recognized to attribute to osteoarthritis (OA) development. These chondrocytes express genes related to unfavorable OA outcomes, emphasizing its importance in OA pathology. BMP7 is being explored as a potential disease-modifying molecule and attenuates the chondrocyte hypertrophic phenotype. On the other hand, BMP7 has been demonstrated to relieve organ fibrosis...

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Share to Bone Morphogenetic Protein 7
Share to Cartilage, Articular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enzyme Activation

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Share to Matrix Metalloproteinase 2

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Source

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Identifiers

PMID: 34608249
DOI: 10.1038/s41598-021-99096-0
PMCID: PMC8490443

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