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Article

MMP13 is a critical target gene during the progression of osteoarthritis

8 Jan 2013

Abstract excerpt

INTRODUCTION: Osteoarthritis (OA) is a degenerative joint disease affecting a large population of people. The mechanism of this highly prevalent disease is not fully understood. Currently there is no effective disease-modifying treatment for OA. The purpose of this study was two-fold: 1) to investigate the role of MMP13 in the development of OA; and 2) to evaluate the efficacy of the MMP13 inhibitor CL82198 as a...

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PMID: 23298463
DOI: 10.1186/ar4133

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