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Article

Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones.

PloS one - 1 Jan 2013

Saito Kenta, Horiuchi Keisuke, Kimura Tokuhiro, Mizuno Sakiko, Yoda Masaki, Morioka Hideo, Akiyama Haruhiko, Threadgill David, Okada Yasunori, Toyama Yoshiaki, Sato Kazuki

Abstract excerpt

TNFα-converting enzyme (TACE) is a membrane-bound proteolytic enzyme with essential roles in the functional regulation of TNFα and epidermal growth factor receptor (EGFR) ligands. Previous studies have demonstrated critical roles for TACE in vivo, including epidermal development, immune response, and pathological neoangiogenesis, among others. However, the potential contribution of TACE to skeletal development is...

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Identifiers

PMID: 23349978
DOI: 10.1371/journal.pone.0054853
PMCID: PMC3548805

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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