Article
Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.
Osteoarthritis and cartilage - 1 Nov 2017
Wang Q, Tan Q Y, Xu W, Qi H B, Chen D, Zhou S, Ni Z H, Kuang L, Guo J Y, Huang J L, Wang X X, Wang Z Q, Su N, Chen L, Chen B, Jiang W L, Gao Y, Chen H G, Du X L, Xie Y L, Chen L
Abstract excerpt
OBJECTIVE: Previous studies have shown that Transforming growth factor-β (TGF-β)/TGFβRII-Smad3 signaling is involved in articular cartilage homeostasis. However, the role of TGF-β/ALK5 signaling in articular cartilage homeostasis has not been fully defined. In this study, a combination of in vitro and in vivo approaches was used to elucidate the role of ALK5 signaling in articular cartilage homeostasis and the...
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