Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes.

Molecular and cellular biology - 1 May 2014

Li Chunliang, Qi Rong, Singleterry Rebecca, Hyle Judith, Balch Amanda, Li Xiuling, Sublett Jack, Berns Hartmut, Valentine Marcus, Valentine Virginia, Sherr Charles J

Abstract excerpt

Injection of transcription activator-like effector nucleases (TALEN) mRNAs into mouse zygotes transferred into foster mothers efficiently generated founder mice with heritable mutations in targeted genes. Immunofluorescence visualization of phosphorylated histone 2A (γH2AX) combined with fluoresc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agouti Signaling Protein
Share to Endonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Histones

Share to Mice, Inbred C57BL

Share to Mice, Inbred Strains

Share to Mosaicism

Share to Zygote

Source

Open in PubMed Open full text

Identifiers

PMID: 24567370
DOI: 10.1128/MCB.00023-14
PMCID: PMC3993595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24567370-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes.PMID 24567370Read ↗

High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases.Semantic proximity Read ↗

Genome Editing in Mice Using TALE Nucleases.Semantic proximity Read ↗

Highly Efficient Targeted Mutagenesis in Mice Using TALENsSemantic proximity Read ↗

A non-inheritable maternal Cas9-based multiple-gene editing system in mice.Semantic proximity Read ↗

Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology.Semantic proximity Read ↗

Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti.Semantic proximity Read ↗

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs.Semantic proximity Read ↗

Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice.Semantic proximity Read ↗

Novel mouse reporter models for the detection of genome editing events in vivoSemantic proximity Read ↗

Zygote Microinjection for Creating Gene Cassette Knock-in and Flox Alleles in Mice.Semantic proximity Read ↗

In vivo genome editing using a high-efficiency TALEN system.Semantic proximity Read ↗

A TALE of two nucleases: gene targeting for the masses?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.