Article

Early mitochondrial gene dysregulation precedes motor neuron degeneration in genomically humanised FUS mutant mice

2026-03-10

Abstract excerpt

<title>Abstract</title> <p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, with mutations in the Fused in Sarcoma (FUS) gene accounting for some of the most aggressive forms of the disease. Although FUS mutations are rare, accounting for only around 5% of all familial ALS cases, they are an important paradigm for study because FUS is an RNA binding protein and disruption to RNA metaboli...

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Literature Corpus work: 1d4a4f25-c253-5ca2-94e4-7b55263aa445
DOI: 10.21203/rs.3.rs-9043045/v1

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