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Generation, quality control, and analysis of the first genomically humanised knock-in mice for the ALS/FTD genes <i>SOD1, TARDBP</i> (TDP-43), and <i>FUS</i>

2021-07-05

Abstract excerpt

<h4>SUMMARY</h4> Amyotrophic lateral sclerosis - frontotemporal dementia spectrum disorder (ALS/FTD) is a complex neurodegenerative disease; up to 10% of cases are familial, usually arising from single dominant mutations in >30 causative genes. Transgenic mouse models that overexpress human ALS/FTD causative genes have been the preferred organism for in vivo modelling. However, while conferring human protein bio...

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Literature Corpus work
a97edaf4-fdd8-5194-95b9-13e41778f329
DOI
10.1101/2021.07.05.451113
Open publication

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