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Article

Characterization of genetic loss-of-function of Fus in zebrafish.

RNA biology - 2 Jan 2017

Lebedeva Svetlana, de Jesus Domingues António M, Butter Falk, Ketting René F

Abstract excerpt

The RNA-binding protein FUS is implicated in transcription, alternative splicing of neuronal genes and DNA repair. Mutations in FUS have been linked to human neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis). We genetically disrupted fus in zebrafish (Danio rerio) using the CRISPR-Cas9 system. The fus knockout animals are fertile and did not show any distinctive phenotype. Mutation of fus...

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Source

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Identifiers

PMID: 27898262
DOI: 10.1080/15476286.2016.1256532
PMCID: PMC5270537

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Characterization of genetic loss-of-function of Fus in zebrafish.PMID 27898262Read ↗

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