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Article

Replication-independent endogenous DNA double-strand breaks in Saccharomyces cerevisiae model.

PloS one - 1 Jan 2013

Thongsroy Jirapan, Matangkasombut Oranart, Thongnak Araya, Rattanatanyong Prakasit, Jirawatnotai Siwanon, Mutirangura Apiwat

Abstract excerpt

Without exposure to any DNA-damaging agents, non-dividing eukaryotic cells carry endogenous DNA double-strand breaks (EDSBs), or Replication-Independent (RIND)-EDSBs. In human cells, RIND-EDSBs are enriched in the methylated heterochromatic areas of the genome and are repaired by an ATM-dependent...

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Share to Chromosomes, Fungal
Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HMGB1 Protein

Share to Long Interspersed Nucleotide Elements

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Share to RNA, Small Interfering

Source

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Identifiers

PMID: 23977341
DOI: 10.1371/journal.pone.0072706
PMCID: PMC3747138

Genes

ATM
HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23977341-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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