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Article

Pin1 acts as a negative regulator of the G2/M transition through an interplay with the Aurora A/hBora complex

1 Jan 2013

Abstract excerpt

Pin1 was the first prolyl isomerase identified that is involved in cell division. The mechanism by which Pin1 acts as a negative regulator of mitotic activity in G2 phase remains unclear. Here, we found that Aurora A can interact with and phosphorylate Pin1 at Ser16, which suppresses the G2/M function of Pin1 by disrupting its binding ability and mitotic entry. Our results also show that phosphorylation of Bora...

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PMID: 23970419
DOI: 10.1242/jcs.121368

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