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Article

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.

Genes & development - 1 Mar 1998

Shen M, Stukenberg P T, Kirschner M W, Lu K P

Abstract excerpt

Phosphorylation of mitotic proteins on the Ser/Thr-Pro motifs has been shown to play an important role in regulating mitotic progression. Pin1 is a novel essential peptidyl-prolyl isomerase (PPIase) that inhibits entry into mitosis and is also required for proper progression through mitosis, but its substrate(s) and function(s) remain to be determined. Here we report that in both human cells and Xenopus extracts,...

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Identifiers

PMID: 9499405
DOI: 10.1101/gad.12.5.706
PMCID: PMC316589

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.PMID 9499405Read ↗

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Requirement of the Prolyl Isomerase Pin1 for the Replication CheckpointSemantic proximity Read ↗

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