Article
The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.
Genes & development - 1 Mar 1998
Shen M, Stukenberg P T, Kirschner M W, Lu K P
Abstract excerpt
Phosphorylation of mitotic proteins on the Ser/Thr-Pro motifs has been shown to play an important role in regulating mitotic progression. Pin1 is a novel essential peptidyl-prolyl isomerase (PPIase) that inhibits entry into mitosis and is also required for proper progression through mitosis, but...
Topics
- Animals
- Antibodies, Monoclonal
- Binding Sites
- Cell Cycle
- Cell Cycle Proteins
- G2 Phase
- HeLa Cells
- Humans
- Mitosis
- Mutation
- NIMA-Interacting Peptidylprolyl Isomerase
- Peptidylprolyl Isomerase
- Phosphoprotein Phosphatases
- Phosphoproteins
- Phosphorylation
- Xenopus
- cdc25 Phosphatases