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Article

Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora

2 Jun 2008

Abstract excerpt

Polo-like kinase 1 (Plk1) and Aurora A play key roles in centrosome maturation, spindle assembly, and chromosome segregation during cell division. Here we show that the functions of these kinases during early mitosis are coordinated through Bora, a partner of Aurora A first identified in Drosophila. Depletion of human Bora (hBora) results in spindle defects, accompanied by increased spindle recruitment of Aurora...

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PMID: 18521620
DOI: 10.1007/s00412-008-0165-5

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