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Article

Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo.

The Journal of pharmacology and experimental therapeutics - 1 Nov 2013

Carnemolla Ronald, Greineder Colin F, Chacko Ann-Marie, Patel Kruti Rajan, Ding Bi-Sen, Zaitsev Sergei, Esmon Charles T, Muzykantov Vladimir R

Abstract excerpt

Thrombomodulin (TM) is a glycoprotein normally present in the membrane of endothelial cells that binds thrombin and changes its substrate specificity to produce activated protein C (APC) that has antithrombotic and anti-inflammatory features. To compensate for loss of endogenous TM in pathology, we have fused recombinant TM with single chain variable fragment (scFv) of an antibody to mouse platelet endothelial...

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Source

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Identifiers

PMID: 23965383
DOI: 10.1124/jpet.113.205104
PMCID: PMC3807068

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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