Article

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis

2001-08-15

Abstract excerpt

The thrombomodulin (TM) gene was ablated in mice in a cell type–restricted manner from vascular endothelium by Cre-recombinase–mediated excision controlled by the endothelial cell lineage–specific Tie2 promoter. Forty percent of mutant (TMLox-) mice display a distinct lethal embryonic phenotype not observed in completely TM-deficient embryos. The remaining 60% of TMLox mice survive beyond birth, but invariably suc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 476ac27a-778a-527c-b94d-4ceaf57f96b3
DOI: 10.1172/jci200113077

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosisDOI 10.1172/jci200113077Read

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosisSemantic proximity Read

Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development.Semantic proximity Read

Characterization of a mouse model for thrombomodulin deficiency.Semantic proximity Read

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.Semantic proximity Read

Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.Semantic proximity Read

Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait.Semantic proximity Read

Thrombomodulin gene disruption and mutation in mice.Semantic proximity Read

Mouse models of vascular development and diseaseSemantic proximity Read

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.Semantic proximity Read

Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue-specific fibrin deposition.Semantic proximity Read

Genetic interactions between the coagulation and fibrinolytic systems.Semantic proximity Read

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodelingSemantic proximity Read