Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis.

The Journal of pharmacology and experimental therapeutics - 1 Mar 2010

Zaitsev Sergei, Zaitzev Sergei, Spitzer Dirk, Murciano Juan-Carlos, Ding Bi-Sen, Tliba Samira, Kowalska M Anna, Bdeir Khalil, Kuo Alice, Stepanova Victoria, Atkinson John P, Poncz Mortimer, Cines Douglas B, Muzykantov Vladimir R

Abstract excerpt

Chemical coupling to carrier red blood cells (RBCs) converts tissue type plasminogen activator (tPA) from a problematic therapeutic into a safe agent for thromboprophylaxis. The goal of this study was to develop a more clinically relevant recombinant biotherapeutic by fusing a mutant tPA with a single-chain antibody fragment (scFv) with specificity for glycophorin A (GPA) on mouse RBCs. The fusion construct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocytes
Share to Fibrinolytic Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycophorins

Share to Hemolysis

Share to In Vitro Techniques

Share to Plasminogen Activators

Share to Single-Chain Antibodies

Share to Venous Thrombosis

Source

Open in PubMed Open full text

Identifiers

PMID: 19952305
DOI: 10.1124/jpet.109.159194
PMCID: PMC2835436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis.PMID 19952305Read ↗

Proof-of-Concept in a Murine Model of Treatment of Thrombotic Thrombocytopenic Purpura Using Engineered Red Blood CellsSemantic proximity Read ↗

Platelet-delivered therapeutics.Semantic proximity Read ↗

Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo.Semantic proximity Read ↗

A Thrombin-Activatable Factor X Variant Corrects Hemostasis in a Mouse Model for Hemophilia A.Semantic proximity Read ↗

The potential improvement of thrombolytic therapy by targeting with bispecific monoclonal antibodies: why they are used and how they are made.Semantic proximity Read ↗

Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.Semantic proximity Read ↗

Tumor endothelium marker-8 based decoys exhibit superiority over capillary morphogenesis protein-2 based decoys as anthrax toxin inhibitors.Semantic proximity Read ↗

Packaging of supplemented urokinase into naked alpha-granules of <i>in vitro</i> -grown megakaryocytes for targeted therapeutic deliverySemantic proximity Read ↗

Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo.Semantic proximity Read ↗

Targeted erythropoietin selectively stimulates red blood cell expansion in vivoSemantic proximity Read ↗

In vivo enrichment of genetically manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low multiplicity of infection.Semantic proximity Read ↗

RGD delivery of truncated coagulase to tumor vasculature affords local thrombotic activity to induce infarction of tumors in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.