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Thrombomodulin Arg403Lys mutation impairs protein C activation and increases thrombosis risk.

Thrombosis research - 1 Aug 2025

Lai Zhe, Yuan Junwei, Li Fang, Zhou Shijie, Wu Xi, Chen Nifei, Wu Wenman, Ding Qiulan, Dai Jing, Hu Xiaobo, Wang Xuefeng, Lu Yeling

Abstract excerpt

Thrombomodulin (TM) is an important regulator in various physiological processes, including coagulation, fibrinolysis and inflammation. TM exerts its cofactor activities for protein C (PC) activation and thrombin-activatable fibrinolysis inhibitor (TAFI) activation through its binding with thrombin. Numerous studies have reported that mutations of TM are associated with thromboembolic diseases. Here we report a...

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Identifiers

PMID: 40494134
DOI: 10.1016/j.thromres.2025.109375

Genes

PC
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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