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Article

Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide.

Circulation research - 26 Oct 2007

True Andrea L, Olive Michelle, Boehm Manfred, San Hong, Westrick Randal J, Raghavachari Nalini, Xu Xiuli, Lynn Edward G, Sack Michael N, Munson Peter J, Gladwin Mark T, Nabel Elizabeth G

Abstract excerpt

Heme oxygenase (HO)-1 (encoded by Hmox1) catalyzes the oxidative degradation of heme to biliverdin and carbon monoxide. HO-1 is induced during inflammation and oxidative stress to protect tissues from oxidative damage. Because intravascular thrombosis forms at sites of tissue inflammation, we hypothesized that HO-1 protects against arterial thrombosis during oxidant stress. To investigate the direct function of...

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Identifiers

PMID: 17885218
DOI: 10.1161/CIRCRESAHA.107.158998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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