Article

POmAb, an antibody targeting open prothrombin, results in anticoagulation without excessive bleeding in mice

2025-07-04

Abstract excerpt

Anti-prothrombin antibodies are commonly found in patients with Antiphospholipid Syndrome (APS), yet their role in clinical manifestations remains unclear. We recently identified two classes of anti-prothrombin antibodies based on their ability to recognize closed and open forms of prothrombin. Type-I antibodies bind to the open form, while Type-II antibodies bind to both forms. POmAb is a prototypical Type-I anti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb6956f2-24d5-5147-a884-ebe429901281
DOI: 10.1101/2025.06.29.662207

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

POmAb, an antibody targeting open prothrombin, results in anticoagulation without excessive bleeding in miceDOI 10.1101/2025.06.29.662207Read

A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis.Semantic proximity Read

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2BSemantic proximity Read

A Novel Single-Domain Antibody Against von Willebrand Factor A1 Domain Resolves Leukocyte Recruitment and Vascular Leakage During Inflammation—Brief ReportSemantic proximity Read

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.Semantic proximity Read

New insights into the biology of tissue factor pathway inhibitor.Semantic proximity Read

Vessel wall BAMBI contributes to hemostasis and thrombus stability.Semantic proximity Read

Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A.Semantic proximity Read

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafishSemantic proximity Read

Gene targeting of components of the fibrinolytic system.Semantic proximity Read

Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins.Semantic proximity Read

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish.Semantic proximity Read

Not fibrin(ogen), but fibrinogen or fibrin.Semantic proximity Read