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Article

The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma.

Pigment cell & melanoma research - 1 Nov 2013

Hacker Elke, Boyce Zachary, Kimlin Michael G, Wockner Leesa, Pollak Thomas, Vaartjes Sam A, Hayward Nicholas K, Whiteman David C

Abstract excerpt

We conducted a clinical trial to compare the molecular and cellular responses of human melanocytes and keratinocytes in vivo to solar-simulated ultraviolet radiation (SSUVR) in 57 Caucasian participants grouped according to MC1R genotype. We found that, on average, the density of epidermal melanocytes 14 days after exposure to 2 minimal erythemal dose (MED) SSUVR was twofold higher than baseline (unirradiated)...

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Identifiers

PMID: 23962207
DOI: 10.1111/pcmr.12157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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