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Article

Mutated Toll-like receptor 9 increases Alzheimer's disease risk by compromising innate immunity protection.

Molecular psychiatry - 1 Dec 2023

Cacace Rita, Zhou Lujia, Hendrickx Van de Craen Elisabeth, Buist Arjan, Hoogmartens Julie, Sieben Anne, Cras Patrick, Vandenberghe Rik, De Deyn Peter P, Oehlrich Daniel, De Bondt An, Engelborghs Sebastiaan, Moechars Diederik, Van Broeckhoven Christine

Abstract excerpt

The development of Alzheimer's disease (AD) involves central and peripheral immune deregulation. Gene identification and studies of AD genetic variants of peripheral immune components may aid understanding of peripheral-central immune crosstalk and facilitate new opportunities for therapeutic intervention. In this study, we have identified in a Flanders-Belgian family a novel variant p.E317D in the Toll-like...

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Identifiers

PMID: 37433968
DOI: 10.1038/s41380-023-02166-0
PMCID: PMC11041692

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