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Article

Investigating the relationship between COMT polymorphisms and working memory performance among childhood brain tumor survivors.

Pediatric blood & cancer - 1 Jan 2014

Howarth Robyn A, Adamson Amanda M, Ashford Jason M, Merchant Thomas E, Ogg Robert J, Schulenberg Stefan E, Ogg Susan, Li Jiang, Wu Shengjie, Xiong Xiaoping, Conklin Heather M

Abstract excerpt

BACKGROUND: Survivors of childhood brain tumors are at increased risk for neurocognitive impairments, including deficits in abilities supported by frontal brain regions. Catechol-O-methyltransferase (COMT) metabolizes dopamine in the prefrontal cortex, with the Met allele resulting in greater dopamine availability and better performance on frontally mediated tasks compared to the Val allele. Given the importance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23956130
DOI: 10.1002/pbc.24649
PMCID: PMC4101980

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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