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Article

Influence of the COMT genotype on working memory and brain activity changes during development.

Biological psychiatry - 1 Aug 2011

Dumontheil Iroise, Roggeman Chantal, Ziermans Tim, Peyrard-Janvid Myriam, Matsson Hans, Kere Juha, Klingberg Torkel

Abstract excerpt

BACKGROUND: The Valine158Methionine (Val158Met) polymorphism of the COMT gene leads to lower enzymatic activity and higher dopamine availability in Met carriers. The Met allele is associated with better performance and reduced prefrontal cortex activation during working memory (WM) tasks in adults. Dopaminergic system changes during adolescence may lead to a reduction of basal dopamine levels, potentially...

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Source

Identifiers

PMID: 21514925
DOI: 10.1016/j.biopsych.2011.02.027

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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