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Article

Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children.

The American journal of psychiatry - 1 Jan 2007

Barnett Jennifer H, Heron Jon, Ring Susan M, Golding Jean, Goldman David, Xu Ke, Jones Peter B

Abstract excerpt

OBJECTIVE: The study aimed to determine the cognitive effect of the Val108/158Met polymorphism in the catechol-O-methyltransferase (COMT) gene in children before and during puberty. This polymorphism affects cognitive function in healthy adults and may contribute to risk for schizophrenia. METHOD: COMT genotype was determined for 8,707 children from the Avon Longitudinal Study of Parents and Children (ALSPAC), a...

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Source

Identifiers

PMID: 17202556
DOI: 10.1176/ajp.2007.164.1.142

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children.PMID 17202556Read ↗

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Adolescence is the starting point of sex-dichotomous COMT genetic effects.Semantic proximity Read ↗

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