Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and neurochemical modulation of prefrontal cognitive functions in children.

The American journal of psychiatry - 1 Jan 2004

Diamond Adele, Briand Lisa, Fossella John, Gehlbach Lorrie

Abstract excerpt

OBJECTIVE: The catechol O-methyltransferase (COMT) gene affects how long dopamine acts in the prefrontal cortex. The Methionine polymorphism, which results in a slower breakdown of prefrontal dopamine, is associated with better adult prefrontal cortex function. The authors investigated the relation between the COMT gene polymorphism and cognitive performance in children. METHOD: Children were tested on cognitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Codon
Share to Cognition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Memory

Share to Prefrontal Cortex

Share to Saliva

Share to Temporal Lobe

Source

Identifiers

PMID: 14702260
DOI: 10.1176/appi.ajp.161.1.125

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and neurochemical modulation of prefrontal cognitive functions in children.PMID 14702260Read ↗

Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents.Semantic proximity Read ↗

Effect of the COMT Val158Met genotype on lateral prefrontal activations in young children.Semantic proximity Read ↗

Genes, cognition and brain through a COMT lens.Semantic proximity Read ↗

Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children.Semantic proximity Read ↗

The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD.Semantic proximity Read ↗

The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD.Semantic proximity Read ↗

Effects of COMT polymorphisms on brain function and behavior in health and disease.Semantic proximity Read ↗

Influence of the COMT genotype on working memory and brain activity changes during development.Semantic proximity Read ↗

Catechol-o-methyltransferase gene and executive function in children with ADHD.Semantic proximity Read ↗

Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers.Semantic proximity Read ↗

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.