C2cd3 is required for cilia formation and Hedgehog signaling in mouse.

doi:10.1242/dev.029835

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Article

C2cd3 is required for cilia formation and Hedgehog signaling in mouse.

Development (Cambridge, England) - 1 Dec 2008

Hoover Amber N, Wynkoop Aaron, Zeng Huiqing, Jia Jinping, Niswander Lee A, Liu Aimin

Abstract excerpt

Cilia are essential for mammalian embryonic development as well as for the physiological activity of various adult organ systems. Despite the multiple crucial roles that cilia play, the mechanisms underlying ciliogenesis in mammals remain poorly understood. Taking a forward genetic approach, we have identified Hearty (Hty), a recessive lethal mouse mutant with multiple defects, including neural tube defects,...

Topics

Animals
Base Sequence
Body Patterning
Calcium Signaling
Central Nervous System
Cilia
DNA Primers
Embryonic Development
Genes, Lethal
Genes, Recessive
Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C3H

Mice, Mutant Strains

Mice, Transgenic

Mutation

Nerve Tissue Proteins

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 19004860
DOI: 10.1242/dev.029835
PMCID: PMC3120044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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