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Article

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Nature genetics - 3 Jul 2011

Garcia-Gonzalo Francesc R, Corbit Kevin C, Sirerol-Piquer María Salomé, Ramaswami Gokul, Otto Edgar A, Noriega Thomas R, Seol Allen D, Robinson Jon F, Bennett Christopher L, Josifova Dragana J, García-Verdugo José Manuel, Katsanis Nicholas, Hildebrandt Friedhelm, Reiter Jeremy F

Abstract excerpt

Mutations affecting ciliary components cause ciliopathies. As described here, we investigated Tectonic1 (Tctn1), a regulator of mouse Hedgehog signaling, and found that it is essential for ciliogenesis in some, but not all, tissues. Cell types that do not require Tctn1 for ciliogenesis require it to localize select membrane-associated proteins to the cilium, including Arl13b, AC3, Smoothened and Pkd2. Tctn1 forms...

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Source

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Identifiers

PMID: 21725307
DOI: 10.1038/ng.891
PMCID: PMC3145011

Genes

TCTN1

Provenance

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Related research

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A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.PMID 21725307Read ↗

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