Article
Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.
PLoS biology - 1 Nov 2013
Cui Cheng, Chatterjee Bishwanath, Lozito Thomas P, Zhang Zhen, Francis Richard J, Yagi Hisato, Swanhart Lisa M, Sanker Subramaniam, Francis Deanne, Yu Qing, San Agustin Jovenal T, Puligilla Chandrakala, Chatterjee Tania, Tansey Terry, Liu Xiaoqin, Kelley Matthew W, Spiliotis Elias T, Kwiatkowski Adam V, Tuan Rocky, Pazour Gregory J, Hukriede Neil A, Lo Cecilia W
Abstract excerpt
Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. This requires PCP/PCP effector proteins, some of which also play essential roles in ciliogenesis, highlighting the long-standing question of the role of the cilium in PCP. Wdpcp, a PCP effector, was recently shown to regulate both ciliogenesis and collective cell movement, but the underlying...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.