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Article

Roles for CEP170 in cilia function and dynein-2 assembly

27 Mar 2024

Abstract excerpt

Primary cilia are essential eukaryotic organelles required for signalling and secretion. Dynein-2 is a microtubule-motor protein complex and is required for ciliogenesis via its role in facilitating retrograde intraflagellar transport (IFT) from the cilia tip to the cell body. Dynein-2 must be assembled and loaded onto IFT trains for entry into cilia for this process to occur, but how dynein-2 is assembled and...

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PMID: 38533689
DOI: 10.1242/jcs.261816

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