Article

A ciliopathy complex builds distal appendages to initiate ciliogenesis

2021-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and super-resolved imaging, we identified a module which we term DISCO (DIStal centriole COmplex). DISCO components CEP90, MNR and OFD1 underlie human ciliopathies. This complex localized to both distal centrioles and centriolar satellites, proteinaceous granules surrounding centrioles....

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Literature Corpus work: f8b26096-6737-52c7-a899-dc08fbe43a8a
DOI: 10.1101/2021.03.01.433418

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