Article
Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction.
Developmental cell - 16 Feb 2010
Ko Hyuk Wan, Norman Ryan X, Tran John, Fuller Kimberly P, Fukuda Mitsunori, Eggenschwiler Jonathan T
Abstract excerpt
Recent findings indicate that mammalian Sonic hedgehog (Shh) signal transduction occurs within primary cilia, although the cell biological mechanisms underlying both Shh signaling and ciliogenesis have not been fully elucidated. We show that an uncharacterized TBC domain-containing protein, Broad-minded (Bromi), is required for high-level Shh responses in the mouse neural tube. We find that Bromi controls ciliary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.