Function of Rieger syndrome gene in left-right asymmetry and craniofacial development.

Abstract excerpt

Rieger syndrome, an autosomal dominant disorder, includes ocular, craniofacial and umbilical abnormalities. The pitx2 homeobox gene, which is mutated in Rieger syndrome, has been proposed to be the effector molecule interpreting left-right axial information from the early embryonic trunk to each organ. Here we have used gene targeting in mice to generate a loss-of-function allele that would be predicted to result...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Body Patterning
• Share to Craniofacial Abnormalities
• Share to Gene Targeting