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Article

Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium.

Developmental biology - 15 Aug 2006

Ai Di, Liu Wei, Ma Lijiang, Dong Feiyan, Lu Mei-Fang, Wang Degang, Verzi Michael P, Cai Chenleng, Gage Philip J, Evans Sylvia, Black Brian L, Brown Nigel A, Martin James F

Abstract excerpt

Current models of left-right asymmetry hold that an early asymmetric signal is generated at the node and transduced to lateral plate mesoderm in a linear signal transduction cascade through the function of the Nodal signaling molecule. The Pitx2 homeobox gene functions at the final stages of this cascade to direct asymmetric morphogenesis of selected organs including the heart. We previously showed that Pitx2...

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Identifiers

PMID: 16836994
DOI: 10.1016/j.ydbio.2006.06.009
PMCID: PMC5851592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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