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Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration

9 Aug 2013

Abstract excerpt

Polysialic acid (polySia), an α-2,8-glycosidically linked polymer of sialic acid, is a developmentally regulated post-translational modification predominantly found on NCAM (neuronal cell adhesion molecule). Whilst high levels are expressed during development, peripheral adult organs do not express polySia-NCAM. However, tumours of neural crest-origin re-express polySia-NCAM: its occurrence correlates with...

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PMID: 23951351
DOI: 10.1371/journal.pone.0073366

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