Article

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene

2021-02-26

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Polysialic acid (PSA) modifies a few cell surface proteins in humans mainly during fetal development and some blood cells in adults. Two genes in humans, ST8SIA2 and ST8SIA4, code for polysialyltransferases that synthesize PSA. The product of ST8SIA2, STX, is highly expressed during fetal development and in many cancers but not in adult normal human cells. The p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4cc30797-97a6-548d-8ea3-b87e2339dad9
DOI: 10.21203/rs.3.rs-246416/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 geneDOI 10.21203/rs.3.rs-246416/v1Read

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 geneSemantic proximity Read

Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders.Semantic proximity Read

Impact of structural aberrancy of polysialic acid and its synthetic enzyme ST8SIA2 in schizophreniaSemantic proximity Read

Aberrant sialylation in a patient with a HNF1α variant and liver adenomatosisSemantic proximity Read

Molecular characterization of eukaryotic polysialyltransferase-1.Semantic proximity Read

Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.Semantic proximity Read

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation.Semantic proximity Read

The Cancer-Associated Antigens Sialyl Lewisa/x and Sda: Two Opposite Faces of Terminal GlycosylationSemantic proximity Read

Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samplesSemantic proximity Read

Total cell N-glycosylation is altered during neuronal differentiation of iPSC to NSC and is disturbed by trisomy 21Semantic proximity Read

Sialylation is involved in cell fate decision during development, reprogramming and cancer progressionSemantic proximity Read

The Role of Sialyl-Tn in CancerSemantic proximity Read